Scientist, Biochemistry/Biophysics

Position: Scientist, Biochemistry/Biophysics

Reporting to: Director, Biology and Biophysics

Employment term: 1-year Contract with possibility of renewal

Start date: Immediate

Location: Mississauga, On

About the Role

Specific Duties & Responsibilities

· Provides GPCR receptor biology and protein biochemistry expertise to support Dalriada’s drug discovery programs

· Designs, Develops, validates, and executes robust assays to facilitate compound screening, and in vitro characterization of GPCR drug candidates

· Troubleshoots and develops technical solutions to optimize experiments for robust data output

· Trains and supervises junior team members

· Monitors, reviews, and critically interprets published research to support experimental efforts

· Carefully documents research workflows, data, and protocols

· Maintains lab notebooks and documents the experimental results in database

· Prepares data summaries and reports to communicate project status among diverse audiences such as project teams and executive boards

Education& Certifications

· PhD in Biochemistry, Biophysics, pharmacology, or related discipline with relevant associated publications

· Post-graduate lab experience in drug discovery settings is desirable but not necessary

Knowledge, Experience & Technical Skills

· Deep knowledge and demonstrated track record in Pharmacology of GPCRs

· Experience in design and execution of plate-based assays and screening and/or characterizing therapeutics targeting GPCRs is a must. Experience with radioligand binding assays is a plus

· Previous experience in small molecule drug discovery

· Full understanding and hands-on experience in development, optimization, and execution of biochemical and biophysical assays techniques for other target classes is highly desirable

· Knowledge and experience in design and generation of the cell lines expressing GPCRs is highly desirable. Familiarity with overexpression, and purification of recombinant protein constructs from E. coli, insect cell and/or mammalian expression systems is an asset.

· Proficient in relevant programs for data analysis and visualization, e.g., GraphPad Prism, Microsoft Excel, Microsoft PowerPoint, Microsoft Word

Skills, Abilities & Competencies

· Ability to analyze, interpret, present scientific data and to propose next steps in both experimental and project design and overall strategy

· Driven by scientific excellence as well as cost and process efficiency

· Offers timely results through use of sound judgement and scientific knowledge

· Thinks critically and generates creative solutions to challenging scientific questions

· Approaches work with an entrepreneurial mindset, often working independently and, able to identify when to reach out for professional input

· Superior communication (written and verbal) and interpersonal skills

· Fast learner, flexible, innovative with the ability to work collaboratively within cross-functional teams

· Ability to handle multiple projects simultaneously and to meet aggressive project timelines


This position is open to applicants legally authorized to work in Canada.

Dalriada Drug Discovery Inc. is an equal opportunity employer, and we are committed to achieving accessibility by providing accommodation for people with disabilities during our hiring process. Accommodation is available on request for qualified candidates during the recruitment process.

All employment is conditional upon completing and obtaining of a satisfactory background check which may include educational, employment, references and criminal records.

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